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Company History

Pharmaceutical business of
POLA Chemical Industries, Inc.
Pharmaceutical business of
KAYAKU Co., Ltd.
Establishment of POLA Chemical Industries, Inc. 1940
1950 Discovery of Colimycin, antibiotics in Fukushima Prefecture
Opening of Shizuoka Factory in Shizuoka, Shizuoka Prefecture 1954 Establishment of Lion-Kinyaku Laboratories
1956 Change of company name to“KAYAKU Antibiotics Research Co., Ltd.”
Implementation of domestic production ofBacitracin, antibiotics
1957 Opening of Itabashi factory in Funado, Itabashi-ku, Tokyo
1959 Agreement with Warner-Lambert Co. for the US and world-wide distribution of Colimycin
Opening of Yokohama Factory in Yokohama, Kanagawa Prefecture, and establishment of mass production system 1961
1963 Development and launch of Orientmycin, antitubercular antibiotics
Establishment of Yokohama R&D Center, offering all modern science resources 1964 Opening of Saitama factory in Fujimino, Saitama Prefecture
1967 Licensed-in of Alosenn, laxative agent, from Schworer GmbH in Germany
1975 Launch of Potassium Gluconate, potassium supplement
Opening of Fukuroi Factory in Fukuroi, Shizuoka Prefecture Entry into pharmaceutical business 1977 Development and launch of Neocarzinostatin anticancer antibiotics by Astellas PharmaInc. (formerly Yamanouchi Pharmaceutical Co., Ltd)
Capital participation in KAYAKU Co., Ltd. Entry into pharmaceutical business 1983 Entry into POLA Group
1984 Change of company name to KAYAKU Co., Ltd.
Establishment of POLA New Drug Research Center 1986 Integration of Research Division into POLA R&D division
1988 Launch of Rubi Parl Series, dermocosmetic products
Establishment of Central R&D Lab. in Yokohama, Kanagawa Prefecture 1992
1994 Smancs, anticancer agent, is co-developed with Kuraray Co., Ltd. and Astellas Pharma, Inc., and launched by Yamanouchi Pharmaceutical Co., Ltd. Integration of Itabashi Factory into Saitama Factory for collective manufacturing
1998 Opening of Tokorozawa factory Factory in Tokorozawa, Saitama Prefecture
Development of Rucinol, a new quasi-drug ingredient for whitening 2002 Modification of Saitama factory. Installation of production line for topical drugs
Approval of first original new drug, “Lulicon Cream /Solution” 2005 Launch of Lulicon Cream/Solution, antifungal topical drug
Transition to a holding company structure


Establishment of POLA PHARMA Inc. by spinning off pharmaceutical division from POLA Chemical Industries, Inc. (Jan.5). Operations start-up after receipt of authorization

Approval of "Divigel®" for the treatment of menopausal distorders
2007 By assignment of production and distribution permit and merger of marketing division into POLA PHARMA,
KAYAKU became the manufacturing specialized company
Co-promotion with GlaxoSmithKline K.K. started for their dermatology products, Kindavate®, Dermovate® and Zovirax® 2009
"Bihada Café", a community for female dermatologists, started its activities 2010
"Lulicon® Ointment", 3rd formulation of "Lulicon®" (antifungal topical products), obtained the regulatory approval

"Medical Mycology Workshop" started for young dermatologists
"POLA PHARMA RISING STAR AWARD" was founded to support the young, spirited dermatology researchers 2014
Started exclusive distribution of GlaxoSmithKline's "DUAC® Combination Gel" for the treatment of acne vulgaris in Japan 2015
Entry into Sun Pharma Group after transition of stock shares from POLA ORBIS HOLDINGS INC. to Sun Pharmaceutical Industries Ltd 2019